Blog page 78



                                               

GRID1

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.

                                               

GRK5

G protein-coupled receptor kinase 5 is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases, and is most highly similar to GRK4 and GRK6. The protein phosphorylates the activated forms of G protein-coupled re ...

                                               

GSTO1

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene. This gene encodes a member of the theta class glutathione-s-transferase-like protein family GSTTL. In Mouse, the encoded protein acts as a small stress re ...

                                               

GSTO2

Model organisms have been used in the study of GSTO2 function. A conditional knockout mouse line called Gsto2 tm2aKOMPWtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to ...

                                               

GTPBP4

Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene. GTP-binding proteins are GTPase and function as molecular switches that can switch between two States: active, when GTP is bound and inactive when GDP is b ...

                                               

H2AFY2

                                               

HABP2

Hyaluronan-binding protein 2 is a protein that in humans is encoded by the HABP2 gene. The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid. It is involved in cell adhesion. This protein is synthesized a ...

                                               

HELLS

Lymphoid-specific helicase is an enzyme that in humans is encoded by the HELLS gene. This gene encodes lymphoid-specific helicase. Other functions helices in processes for the separation of DNA, including replication, repair, recombination and tr ...

                                               

HIF1AN

                                               

HK1

Hexokinase-1 is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hex ...

                                               

HNRPF

Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins. The hnRNPs are RNA binding proteins that c ...

                                               

HNRPH3

Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins hnRNPs. In hnRNPs are RNA binding protein ...

                                               

HOGA1

4-Hydroxy-2-oxoglutarate aldolase, mitochondrial also known as dihydrodipicolinate synthase-like is an enzyme that in humans is encoded by the HOGA1 gene. The protein is one of the enzymes involved in metabolism of hydroxyproline to glyoxylate. T ...

                                               

HPS1

Hermansky–Pudlak syndrome 1 protein is a protein that in humans is encoded by the HPS1 gene. This gene encodes a protein that may play a role in organelle biogenesis associated with melanosome, platelet dense granules and lysosomes. The encoded p ...

                                               

HPS6

This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. HPS6 along with HPS3 and HPS5 form a stable protein complex named Biogenesis of Lysosome-rela ...

                                               

HPSE2

                                               

HTRA1

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kaza ...

                                               

IFIT1

                                               

IFIT2

IFIT2 may play a role in prevention of tumor progression. Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different ...

                                               

IFIT3

                                               

IL-2 receptor

The interleukin-2 receptor is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.

                                               

IL2RA

Interleukin-2 receptor alpha chain is a protein that in humans is encoded by the IL2RA gene. To the Il-2 IL2 gene il2ra receptor alpha and beta chain IL2RB, together with the common gamma chain IL2RG, constitute the high-affinity IL2 receptor. Ho ...

                                               

INPP5A

Type I inositol-1.4.5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. The protein encoded by this gene, is associated with a membrane of the type I Inositol 1.4.5-triphosphate InsP3 5-phosphatase. InsP3 5-ph ...

                                               

INPP5F

The protein encoded by this gene is an inositol 1.4.5-trisphosphate InsP3 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4.5-bisphosphate and phosphatidylinositol 3.4.5-trisphosphate. Al ...

                                               

Insulin-degrading enzyme

Insulin-degrading enzyme, also known as IDE, is an enzyme. Also known as insulysin or insulin protease, IDE is a large zinc-binding protease of the metalloprotease family, M16 known to cleave multiple short polypeptides that vary considerably in ...

                                               

Integrin alpha 8

                                               

Integrin beta 1

Integrin beta-1, also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It a ...

                                               

Interleukin 15 receptor, alpha subunit

The IL-15 receptor is composed of three subunits: IL-15R alpha, CD122, and CD132. Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit CD25. The shared subunits contain the cyt ...

                                               

Internexin

Internexin, alpha-internexin, is a Class IV intermediate filament approximately 66 KDa. The protein was originally purified from rat optic nerve and spinal cord. The protein copurifies with other neurofilament subunits, as it was originally disco ...

                                               

Isopentenyl-diphosphate delta isomerase

Isopentenyl pyrophosphate isomerase, also known as Isopentenyl-diphosphate delta isomerase, is an isomerase that catalyzes the conversion of the relatively un-reactive isopentenyl pyrophosphate to the more-reactive electrophile dimethylallyl pyro ...

                                               

ITIH2

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene. It is known to contain a GLA domain, and, therefore, to be dependent for production on the post-translational modification, requires vitamin K. ...

                                               

JAKMIP3

                                               

KAZALD1

                                               

KIAA0157

                                               

KIAA1279

KIF1-binding protein, also known as Kinesin binding protein, is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equa ...

                                               

KIF5B

                                               

KIN (gene)

DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene. The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the course of the enlightenment ...

                                               

Kinesin family member 11

Kinesin-5 is a molecular motor protein that is essential in mitosis. Kinesin-5 proteins are members of kinesin superfamily, which are nanomotors that move along microtubule tracks in the cell. Named from studies in the early days of discovery, it ...

                                               

LBX1

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene. This gene and the gene orthologous mouse was found by their homology to the Drosophila Lady bird early and late homeobox genes. In the Mouse this gene is a key reg ...

                                               

LDB1

                                               

LDB3

LIM domain binding 3, also known as Z-band alternatively spliced PDZ-motif, is a protein which in humans is encoded by the LDB3 gene. ZASP belongs to the Enigma subfamily of proteins and stabilizes the sarcomere during contraction, through intera ...

                                               

LGI1

The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside th ...

                                               

Lipase a, lysosomal acid type

This gene encodes lipase A, the lysosomal acid lipase also known as cholesterol ester hydrolase. This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman ...

                                               

Lipase member N

The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4.

                                               

LOXL4

Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene. This gene encodes a family member of the gene lysyl oxidase. The prototype member of the family is essential for biogenesis of connective tissue, encoding an extrac ...

                                               

Mannose receptor

The mannose receptor is a C-type lectin primarily present on the surface of macrophages, immature dendritic cells and liver sinusoidal endothelial cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and kera ...

                                               

Mannose receptor C-type 1

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this g ...

                                               

MAP3K8

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the ERK1/2 and p38 MAP kinases. This kinase was shown to activa ...

                                               

MAPK8

The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiati ...

                                               

MARCH5

E3 ubiquitin-protein ligase MARCH5, also known as membrane-associated ring finger 5, is an enzyme that, in humans, is encoded by the MARCH5 gene. It is localized in the mitochondrial outer membrane and has four transmembrane domains.

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