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Cyclin D1

The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the long arm of chromosome 11 band 11q13. It is 13.388 base pairs long, and translates into 295 amino acids. Cyclin D1 is expressed in all adult human tissues with t ...

                                               

CYP2R1

Vitamin D 25-hydroxylase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. ...

                                               

DAK (gene)

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4.5-phosphate ak ...

                                               

DBX1

Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal c ...

                                               

DCHS1

Protein dachsous homolog 1, also known as protocadherin-16 or cadherin-19 or cadherin-25 or fibroblast cadherin-1, is a protein that in humans is encoded by the DCHS1 gene.

                                               

DDB1

The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small DDB2 subunit. DDB1 contains 1140 amino acids, amounting to a mass of 127 kDa.

                                               

DDB2

As indicated by Rapic-Otrin et al. in 2003, the DDB2 gene is located on human chromosome 11p11.2, spans a region of approximately 24 – 26 kb and includes 10 exons. The DDB2 protein contains five putative WD40 repeats sequences of about 40 amino a ...

                                               

DDX6

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene. Dead box proteins, characterized by conservative motif ASP-STU-Ala-ASP, dead putative RNA helicase. They are involved in a number of cellular proces ...

                                               

DDX10

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene. Dead box proteins, characterized by conservative motif ASP-STU-Ala-ASP, dead putative RNA helicase. They are involved in a number of cellular proc ...

                                               

Deltex e3 ubiquitin ligase 4

                                               

DGKZ

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene. The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It can weaken the protein kinases activity C by regulating the level of d ...

                                               

Diacylglycerol O-acyltransferase 2

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations ...

                                               

DKK3

Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic developm ...

                                               

DLG2

Disks large homolog 2 also known as channel-associated protein of synapse-110 or postsynaptic density protein 93 is a protein that in humans is encoded by the DLG2 gene.

                                               

DNA polymerase alpha subunit 2

                                               

Down syndrome cell adhesion molecule like 1

                                               

DRAP1

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene. Repression of transcription is a common mechanism to regulate transcription initiation of organisms, ranging from yeast to humans. Accurate initiation of transcr ...

                                               

Dual specificity phosphatase 8

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negati ...

                                               

DYNC2H1

Cytoplasmic dynein 2 heavy chain 1 is a protein that in humans is encoded by the DYNC2H1 gene. It is associated with short rib-polydactyly syndrome of type 3. It is also associated with asphyxiating thoracic dysplasia.

                                               

EFEMP2

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene. A large number of extracellular matrix proteins was discovered variations of the epidermal growth factor EGF domain and has been ...

                                               

EHD1

EH domain-containing protein 1, also known as testilin or PAST homolog 1, is a protein that in humans is encoded by the EHD1 gene belonging to the EHD protein family.

                                               

EI24

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene. This gene has higher expression in p53-expressing cells than in control cells and is an immediate early induction target of p53-mediated apoptosis. The ...

                                               

EIF3F

                                               

EIF3M

Eukaryotic translation initiation factor 3, subunit M also known as PCI domain containing 1, is a protein that in humans is encoded by the EIF3M gene. HFLB5 encodes generally expressed protein that contains the putative membrane fusion Domains th ...

                                               

EIF4G2

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F eIF4F, which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein enco ...

                                               

ELP4

This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenoty ...

                                               

EMSY

                                               

EPS8L2

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene. This gene encodes a protein that belongs to the receptor of the epidermal growth factor pathway substrate 8 EPS8, a subs ...

                                               

ESAM (gene)

                                               

Excitatory amino acid transporter 2

Excitatory amino acid transporter 2 also known as solute carrier family 1 member 2 and glutamate transporter 1 is a protein that in humans is encoded by the SLC1A2 gene. Alternatively spliced transcript variants of this gene have been described, ...

                                               

EXPH5

                                               

EXT2 (gene)

Exostosin glycosyltransferase-2 is a protein that in humans is encoded by the EXT2 gene. This gene encodes one of two glycosyltransferases involved in the chain elongation step of the biosynthesis of heparan sulfate. Mutations in this gene cause ...

                                               

FADS2

This article is about the gene, for main associated enzyme see D6D. Fatty acids desaturase 2 is encoded by FADS2 gene associated enzyme is sometimes called FADS2 as well. Its main associated enzyme, however, the Delta-6 desaturase D6D human enzym ...

                                               

FAM76B

                                               

FAM118B

                                               

Family with sequence similarity 111 member a

The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide PIP box, that is necessary for its ...

                                               

FANCF

FANCF is an adaptor protein that plays a key role in the proper assembly of the FA core complex. The FA core complex is composed of eight proteins FANCA, -B, -C, -E, -F, -G, -L and -M. FANCF stabilizes the interaction between the FANCC/FANCE subc ...

                                               

Fat atypical cadherin 3

                                               

FAU (gene)

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus FBR-MuSV. It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N-terminus and ribosomal protein S30 at the C-termin ...

                                               

KDM2A

Lysine-specific demethylase 2A also known as F-box and leucine-rich repeat protein 11 is an enzyme that in humans is encoded by the KDM2A gene. KDM2A is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem ...

                                               

FCHSD2

                                               

FERMT3

Fermitin family homolog 3), also known as kindlin-3, MIG2-like protein, or unc-112-related protein 2 is a protein that in humans is encoded by the FERMT3 gene. The kindlin family of proteins, member of the B4.1 superfamily, comprises three conser ...

                                               

FEZ1

Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene. This gene is the ortholog of C. elegans UNC-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. The expres ...

                                               

FGF3

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 FGFR3 to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes withi ...

                                               

FGF4

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene. The protein encoded by this gene is a member of a family of fibroblast growth factor FGF. The FGF family members possess broad mitogenic and survival activities o ...

                                               

FIBP

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to a ...

                                               

FJX1

The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact func ...

                                               

FKBP2

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase th ...

                                               

Flap structure-specific endonuclease 1

The protein encoded by this gene removes 5 overhanging "flaps" or short sections of single stranded DNA that "hang off" because their nucleotide bases are prevented from binding to their complementary base pair - despite any base pairing downstre ...

                                               

FLRT1

This gene encodes a member of the fibronectin leucine rich transmembrane protein FLRT family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in ...

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