Blog page 98



                                               

RNF26

The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived f ...

                                               

RNH1

                                               

RNU2-2

                                               

ROBO3

                                               

ROBO4

                                               

ROM1

Rod outer segment membrane protein 1 is a protein that in humans is encoded by the ROM1 gene. This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. T ...

                                               

RPS6KA4

This gene encodes a member of the RSK ribosomal S6 kinase family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptiona ...

                                               

RPS6KB2

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene. This gene encodes a member of the RSK ribosomal S6 kinase family of Serine / threonine kinases. This kinase contains two non-identical kinase catalytic ...

                                               

RRAS2

                                               

RRM1

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene. This gene encodes one of two non-identical subunits, which closely resembles the make-diphosphate-reductase, an enzyme required for produc ...

                                               

RSF1

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene. HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis b virus X protein HBX, and chromatin remodeling and ...

                                               

RTN3

Reticulon-3 is a protein that in humans is encoded by the RTN3 gene. In reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues.

                                               

SAA2

                                               

SAC3D1

                                               

Sarcolipin

Sarcoplasmic reticulum Ca 2+ -ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca 2+ from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. The SLN gene encodes a small transmembrane proteoli ...

                                               

SART1

U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene. This gene encodes two proteins, the SART1 protein expressed in the nucleus of the majority of proliferating cells, and the SART1 protein expressed i ...

                                               

SBF2

Myotubularin-related protein 13 is a protein that in humans is encoded by the SBF2 gene. The family of myotubularin-related proteins includes lipid phosphatases, such as MTM1 MIM 600415 and pseudophosphatases such as MIM 603560 SBF1 and SBF2. Pse ...

                                               

SCGB1D2

The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are wide ...

                                               

SCYL1

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences throug ...

                                               

Serum amyloid A1

Serum amyloid A1 is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is pre ...

                                               

SESN3

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase Akt and ...

                                               

SF1 (gene)

Splicing factor 1 also known as zinc finger protein 162 is a protein that in humans is encoded by the SF1 gene. Splicing factor PF1 is involved in the ATP-dependent formation of the spliceosome complex.Gene PF1 is necessary to make the bipotentia ...

                                               

SF3B2

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex U2 snRNP. The splicing factor 3b/3a complex bind ...

                                               

SHANK2

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature ...

                                               

SIGIRR

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene. It is observed for the modulation of immune responses, intestinal epithelial homeostasis and tumorigenesis.

                                               

Sirtuin 3

NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene. SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT3 exhi ...

                                               

SLC22A8

OAT3 is involved in the transport and excretion of organic ions some of which are drugs e.g., penicillin G benzylpenicillin, methotrexate MTX, indomethacin an NSAID, and ciprofloxacin a fluoroquinolone antibiotic) and some of which are pure toxic ...

                                               

SLC22A18

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndro ...

                                               

Small nucleolar rna host gene 1

This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regul ...

                                               

SNF1LK2

                                               

Solute carrier family 25 member 22

Solute carrier family 25 member 22 is a protein that in humans is encoded by the SLC25A22 gene. This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Expression o ...

                                               

SPA17

Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene. This gene encodes a protein present at the cell surface. Studies in rabbits suggest that the sperm protein involved in fertilization by binding to the Zona pellu ...

                                               

Sphingomyelin phosphodiesterase 1

Sphingomyelin phosphodiesterase 1, also known as acid sphingomyelinase, is an enzyme that in humans is encoded by the SMPD1 gene. Sphingomyelin phosphodiesterase 1 belongs to the sphingomyelin phosphodiesterase family.

                                               

SPTBN2

                                               

SSH3

The ADF actin-depolymerizing factor/cofilin family see MIM 601442 is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 LIMK1, MIM 601329. The SSH family appear ...

                                               

ST3GAL4

                                               

ST5 (gene)

Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene. ST5 orthologs have been identified in nearly all mammals for which complete genome data are available.

                                               

STARD10

StAR-related lipid transfer protein 10 or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene. The protein derives its name from the fact that the molecule contains a START domain. As part of the StarD2 sub ...

                                               

Sterol-C5-desaturase-like

Lathosterol oxidase is an enzyme that in humans is encoded by the SC5DL gene. This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene h ...

                                               

STIM1

Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. Even if the protein ha ...

                                               

STS-1 (gene)

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene. This gene encodes a protein containing a ubiquitin domain protein binds in the N-Terminus, SH3 domain, and a C-terminal domain si ...

                                               

Stt3a, catalytic subunit of the oligosaccharyltransferase complex

The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase OST complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containin ...

                                               

Sulfonylurea receptor

In molecular biology, the sulfonylurea receptors are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specif ...

                                               

SUV420H1

Histone-lysine N-methyltransferase SUV420H1 is an enzyme that in humans is encoded by the SUV420H1 gene. The enzyme along with WHSC1 is responsible for dimethylation of lysine 20 on histone 4 in mouse and humans. This gene encodes a protein conta ...

                                               

SYT7

Synaptotagmins, such as SYT7, are brain-specific calcium-dependent phospholipid-binding proteins that play a role in synaptic exocytosis and neurotransmitter release. See MIM 600782.

                                               

SYT13

SYT13 belongs to the large synaptotagmin protein family. All synaptotagmins show type I membrane topology, with an extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions ...

                                               

SYTL2

The protein encoded by this gene is a synaptotagmin-like protein SLP that belongs to a C2 domain-containing protein family. The SLP homology domain SHD of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein ...

                                               

SYVN1

This gene encodes a protein involved in endoplasmic reticulum ER-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the u ...

                                               

T-cell surface glycoprotein CD3 epsilon chain

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an import ...

                                               

TAF6L

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID TFIID, which binds to the core promoter to position the polymerase pr ...

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