Dolutegravir/lamivudine/tenofovir is a medication used to treat HIV/AIDS. It is a combination of dolutegravir, lamivudine, and tenofovir disoproxil. As of 2019, it is listed by the World Health Organization as the first line treatment for adults, with tenofovir/lamivudine/efavirenz as an alternative. It is taken by mouth. Side effects may include trouble sleeping, weight gain, and rash. While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. Use remains recommended after the first trimester. Use is not recommended in those with kidney problems. The combination is a type of antiretroviral therapy. It is on the World Health Organizations List of Essential Medicines, the safest and most effective medicines needed in a health system. In some countries it is available as a generic medication. In the developing world it costs about US$75 per year. It is tentatively approved in the United States as of 2019, full approval is pending expiration of the US patents on dolutegravir Tivicay and tenofovir disoproxil fumarate Viread.
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